P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling. P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets.

Search results for p-selectin at Sigma-Aldrich. Summary: This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes.

(12) surprisingly demonstrated the  P-selectin P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene. P-selectin functions as a cell adhesion molecule ( CAM)  P-selectin' (PADGEM, GMP-140, CD62) and E-selectin. (ELAM-1) are cell adhesion molecules that mediate the in- teraction of platelets and endothelial cells with  P-selectin has been shown to be upregulated on circulating platelets and pulmonary endothelium of patients with PAH and corresponding rat models (6, 7) . Mar 5, 2020 Blocking P-selectin with mAb alleviated renal tubulointerstitial fibrosis, renal hypoxia, and peritubular capillary loss, without alteration of the levels  Apr 25, 2016 P-selectin expression significantly (P<0.05) increases when platelets are activated during hypertension. Although P‑selectin recruits leukocytes  The Mouse P-selectin - IgG Fusion Protein is composed of the signal sequence, the lectin domain, the EGF-like repeat, and the first two complement-binding  Flowing leukocytes tether to and roll on P-selectin, a receptor on endothelial cells that is rapidly internalized in clathrin-coated pits.

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39 In a baboon model, P-selectin expression increased after P-selectin is an adhesion receptor for leukocytes expressed by activated platelets and endothelial cells. To assess a possible role of P-selectin in platelet clearance, we adapted an in vivo biotinylation technique in mice. Wild-type and P-selectin–deficient mice were infused with N-hydroxysuccinimido biotin. Our data indicate that P-selectin, but not E-selectin, is directly involved in eosinophil tethering on inflammatory endothelium while L-selectin mainly mediates intereosinophil interaction. VLA-4 has a crucial role in eosinophil arrest, and arrest is enhanced by exposure to chemoattractants. P‑Selectin/CD62P in Mouse Liver.

selectin: ( sĕ-lek'tin ), A cell surface molecule involved in immune adhesion and cell trafficking. [L. se-ligo, pp. se-lectum, to sort, choose, + -in]

: 561306. Märke. : Millipore.

P-selectin mediates neutrophil rolling and recruitment in acute pancreatitis. Artikel i interactions in the pancreas remain elusive, but selectins may play a role.

PECAM-1. Naive HUVEC + Exposed U937. P-selectin binder till P-selectin glycoprotein ligand 1 PSGL-1 på monocyten, andra leukocyter och endotel.Leder till adhesion av trombocyten till leukocyt och  RCP9130, Prolactin, 1 mg.

REACH- registreringsnummer: Denna produkt är en blandning. Millipore Referens. Hitta stockbilder i HD på p selectin och miljontals andra royaltyfria stockbilder, illustrationer och vektorer i Shutterstocks samling.
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Kumar, Vinay, Abul K. Abbas,  Dec 14, 2014 In this video we discuss the three different types of selectins and their P- Selectin and Pulmonary Arterial Thrombosis in Trauma and Disease  P-Selektin. Synonyme: GRMP, CD62, LECAM3, PSEL, Selektin P, CD62P, GMP140 Englisch: P-selectin, selectin P  P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene.P-selectin functions as a cell adhesion molecule (CAM) on the  Selectin P ligand, also known as SELPLG or CD162 (cluster of differentiation 162 ), is a human gene.
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Every selectin has  Jan 4, 2013 diapedesis, selectin family of adhesion molecules, E-selectin, P-selectin, and chemotaxis are all explained. Kumar, Vinay, Abul K. Abbas,  Dec 14, 2014 In this video we discuss the three different types of selectins and their P- Selectin and Pulmonary Arterial Thrombosis in Trauma and Disease  P-Selektin. Synonyme: GRMP, CD62, LECAM3, PSEL, Selektin P, CD62P, GMP140 Englisch: P-selectin, selectin P  P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene.P-selectin functions as a cell adhesion molecule (CAM) on the  Selectin P ligand, also known as SELPLG or CD162 (cluster of differentiation 162 ), is a human gene. SELPLG codes for PSGL-1, the high affinity  For transfection of specific primary cells, e.g. mouse macrophages, in the 4D- Nucleofector™ X Unit (20 µL format).

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(ELAM-1) are cell adhesion molecules that mediate the in- teraction of platelets and endothelial cells with  P-selectin has been shown to be upregulated on circulating platelets and pulmonary endothelium of patients with PAH and corresponding rat models (6, 7) . Mar 5, 2020 Blocking P-selectin with mAb alleviated renal tubulointerstitial fibrosis, renal hypoxia, and peritubular capillary loss, without alteration of the levels  Apr 25, 2016 P-selectin expression significantly (P<0.05) increases when platelets are activated during hypertension. Although P‑selectin recruits leukocytes  The Mouse P-selectin - IgG Fusion Protein is composed of the signal sequence, the lectin domain, the EGF-like repeat, and the first two complement-binding  Flowing leukocytes tether to and roll on P-selectin, a receptor on endothelial cells that is rapidly internalized in clathrin-coated pits. We asked whether the  P-selectin is a leukocyte adhesion receptor present in endothelial cells and platelets. We examined the role of P-selectin in the autologous phase of an  Purpose. Vascular endothelial cells and leukocytes express several inflammatory adhesion receptors, such as selectins and cell adhesion molecules, after  PE anti-human CD62P (P-Selectin) Antibody - CD62P is a 140 kD type I transmembrane glycoprotein also known as P-selectin, platelet activation- dependent  Oct 4, 2017 Selectins are carbohydrate-binding proteins that are physiologically expressed on the surface of endothelial cells (P-selectin and E-selectin),  The adhesion molecule P-selectin (CD62P) is of interest because of its role in modulating interactions between blood cells and the endothelium, and also  Crystal structure of P-selectin lectin/EGF domains complexed with SLeX 1 Introduction; 2 3D structure; 3 Different roles of P-selectin. 3.1 Role in leukocyte  Mar 15, 1998 Basically, ligands for L-selectin are found on endothelial cells while ligands for E- and P-selectins are found on leukocytes.